Wyoming may be famous for Yellowstone, cowboys, and wide-open skies, but its cities are also vibrant business hubs that offer opportunities and economic growth. Although Wyoming is the least populated U.S. state, its cities punch above their weight with strong economies, low taxes, and business-friendly environments.

Whether you’re considering moving, investing, or launching a startup, understanding Wyoming’s major cities is crucial. Below, we explore the five biggest cities in Wyoming by population, complete with statistics, largest employers, top industries, and realistic business growth projections.

1. Cheyenne, Wyoming

• Population: 65,168
• County: Laramie County
• Median Household Income: $71,901
• Unemployment Rate: 2.8%
• Largest Employer: F.E. Warren Air Force Base

Overview

Cheyenne is the heartbeat of Wyoming. Founded in 1867 as a Union Pacific Railroad hub, it quickly became the state capital and center of government and commerce. Today, it blends tradition and progress, maintaining its Western charm while offering modern infrastructure.

Top Industries

• Government and Military
• Transportation and Logistics
• Healthcare
• Telecommunications
• Retail and Services

Business Growth Projections

Cheyenne is projected to see steady growth at 1.5%–2% annually through 2030, driven by expansions in logistics, warehousing, and remote work infrastructure. Growth in telecommunication hubs and data centers is also expected to continue as tech companies seek low-cost, low-tax environments.

Best Business Opportunities

• Third-party logistics (3PL) services
• E-commerce fulfillment centers
• Data hosting and cybersecurity startups
• Healthcare clinics and urgent care centers
• Real estate investment for remote workers

Life in Cheyenne

Residents enjoy the annual Cheyenne Frontier Days rodeo, historic architecture, an emerging brewery scene, and strong community events. Its proximity to Denver allows businesses access to a larger market while benefiting from Wyoming’s favorable tax laws.

2. Casper, Wyoming

• Population: 58,720
• County: Natrona County
• Median Household Income: $67,859
• Unemployment Rate: 3.2%
• Largest Employer: Wyoming Medical Center

Overview

Casper, known as “The Oil City,” has roots in energy exploration and oil refining. Today, while energy still plays a critical role, the city has diversified into healthcare, education, and manufacturing sectors, ensuring a more stable economy for the future.

Top Industries

• Energy Production and Services
• Healthcare
• Manufacturing
• Retail and Hospitality
• Education

Business Growth Projections

Casper’s economy is projected to grow at a stable rate of 1%–1.5% annually, with diversification being key. Healthcare and light manufacturing are expected to lead growth. Casper also aims to attract more tourism-focused businesses tied to outdoor recreation.

Best Business Opportunities

• Energy services and consulting firms
• Specialized healthcare practices (pediatrics, physical therapy)
• Small-scale manufacturing (machinery, parts)
• Outdoor gear retailers and adventure tour companies
• Senior living facilities and home health services

Life in Casper

The city offers a rich cultural life including the Nicolaysen Art Museum, annual events like the Central Wyoming Fair, and abundant outdoor activities from fly-fishing to skiing at nearby Hogadon Basin.

3. Gillette, Wyoming

• Population: 33,496
• County: Campbell County
• Median Household Income: $83,942
• Unemployment Rate: 3.0%
• Largest Employer: Campbell County Health

Overview

Gillette powers the nation. Positioned within the Powder River Basin, it produces a major portion of the U.S. coal supply. Although energy remains king, Gillette’s leadership has worked hard to diversify the economy in recent years.

Top Industries

• Coal and Energy Mining
• Healthcare
• Equipment Manufacturing
• Construction and Engineering Services
• Education and Training

Business Growth Projections

Gillette’s economy is forecasted to grow at 1.2%–2% annually, contingent on the global energy market. However, renewable energy technology, manufacturing, and healthcare are rapidly emerging sectors ready to create new growth paths.

Best Business Opportunities

• Renewable energy installation and maintenance companies
• Industrial equipment maintenance and repair firms
• Healthcare and mental health services
• Vocational and technical training centers
• Real estate development for workforce housing

Life in Gillette

While smaller than Cheyenne and Casper, Gillette provides excellent recreational facilities, easy access to Devils Tower and Keyhole State Park, and high median incomes due to energy sector wages.

4. Laramie, Wyoming

• Population: 32,152
• County: Albany County
• Median Household Income: $54,735
• Unemployment Rate: 3.3%
• Largest Employer: University of Wyoming

Overview

Laramie has always been defined by education and innovation. It’s the home of the University of Wyoming and has long attracted intellectual, cultural, and outdoor enthusiasts. Its economy is now growing to include tech, research, and manufacturing.

Top Industries

• Education and Research
• Advanced Manufacturing
• Information Technology
• Tourism and Recreation
• Agriculture Support Services

Business Growth Projections

Laramie is expected to grow steadily at 1.5%–2% per year through 2032, primarily fueled by tech startups, university research projects, and tourism tied to Wyoming’s natural beauty.

Best Business Opportunities

• Technology startups (software development, cybersecurity)
• Consulting firms tied to university research (engineering, environment)
• Boutique hotels and outdoor adventure tour companies
• Craft breweries and specialty food producers
• Agricultural tech services (drone surveying, soil analysis)

Life in Laramie

With hiking, mountain biking, skiing, and vibrant university life, Laramie maintains an exciting balance between small-town friendliness and cultural sophistication. The cost of living is attractive compared to larger metro areas.

5. Rock Springs, Wyoming

• Population: 22,954
• County: Sweetwater County
• Median Household Income: $79,734
• Unemployment Rate: 3.5%
• Largest Employer: Rocky Mountain Power

Overview

Rock Springs, originally a coal mining town, has evolved into a multi-industry city. With a strong presence of utilities, transportation, energy, and healthcare sectors, Rock Springs remains vital to southwestern Wyoming’s economy.

Top Industries

• Energy Production
• Utilities and Infrastructure
• Transportation and Warehousing
• Healthcare Services
• Retail and Trade

Business Growth Projections

Rock Springs anticipates moderate growth of 1%–1.3% annually over the next decade. Growth is expected mainly in infrastructure projects, renewable energy services, and expansion of healthcare facilities.

Best Business Opportunities

• Renewable energy consultants and technicians
• Logistics and transportation services
• Specialty construction companies (solar, wind, utilities)
• Healthcare services expansion (outpatient and specialty care)
• Tourism services for Flaming Gorge and Red Desert visitors

Life in Rock Springs

Rock Springs offers a rich outdoor lifestyle, a strong sense of heritage, and easy access to some of Wyoming’s most scenic areas. Housing remains affordable, and the local economy supports skilled trades and small businesses.

Conclusion: Wyoming’s Cities are Poised for the Future

Although Wyoming is often associated with rugged landscapes and small-town life, its cities are modernizing, diversifying, and growing. Each city offers unique business opportunities and competitive advantages:

• Cheyenne thrives on government, logistics, and data hosting.
• Casper balances energy, healthcare, and tourism.
• Gillette remains a mining powerhouse while investing in renewable industries.
• Laramie shines in education, tech, and manufacturing.
• Rock Springs anchors infrastructure, energy, and healthcare expansion.

Wyoming’s business-friendly tax policies, combined with strong community support, low cost of living, and breathtaking surroundings, make it one of the best states for launching a new business or expanding your reach.

If you’re considering making a move or starting a new venture, Wyoming’s cities offer real opportunities with a frontier spirit that still welcomes bold thinkers and builders.